Multiple Sclerosis Activity May Be Affected By Prozac

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A brand new research revealed within the Journal of
Neurology Neurosurgery and Psychiatry
finds that Prozac, a
generally prescribed antidepressant, could also be an agent in slowing
down the illness technique of the relapsing remitting type of a number of
sclerosis (MS).

Multiple sclerosis is an autoimmune illness the place the immune system
assaults the central nervous system. Within the relapsing remitting kind,
new signs happen in discrete assaults.

A crew of researchers led by J P Mostert (Division of Neurology,
College Medical Heart Groningen, College of Groningen,
Groningen, The Netherlands) performed a double-blind,
placebo-controlled, exploratory evaluation of 40 sufferers
with the relapsing
remitting type of MS. For a interval of 24 weeks, half of the pattern was
handled with 20 mg each day of fluoxetine
(Prozac) whereas the opposite half obtained a placebo. To measure the
exercise of MS, detailed magnetic resonance photos (MRI) of the
individuals’ brains have been accomplished each 4 weeks. The researchers
centered on areas of neurological inflammation that may point out
lively illness.

Of the 40 preliminary sufferers, 19 individuals in every group completed the
research. The principle discovering was that the sufferers who have been handled with
Prozac had fewer new areas of irritation than these handled with
placebo. The researchers have been in a position to detect the consequences simply after
eight weeks – the identical period of time that it takes for selective
serotonin reuptake inhibitor
(SSRI) medication akin to Prozac to start relieving depression.

Particularly, the group given placebo had a mean of over 5 new
areas affected with irritation in comparison with simply lower than two areas
within the Prozac group. Twenty-five p.c of scans from Prozac-treated
sufferers and forty p.c of placebo-treated sufferers depicted new
areas of irritation. Nearly two out of three sufferers within the Prozac
group had no new irritation areas over the past 16 weeks of
therapy, whereas solely about 25% of sufferers within the placebo group had
no new areas.

Though this was a small-scale research and a bigger pattern dimension is
required to extend the robustness of outcomes, the authors conclude
that, “Outcomes of our exploratory trial are sufficiently encouraging to
justify additional research with fluoxetine in sufferers with MS. Larger
doses of fluoxetine and mixture therapy with immunomodulatory
medication needs to be thought-about.”

Results of fluoxetine on illness exercise in relapsing
a number of sclerosis: a double-blind, placebo-controlled, exploratory

J P Mostert, F Admiraal-Behloul, J M Hoogduin, J Luyendijk, D J
Heersema, M A van Buchem, J De Keyser
Journal of Neurology
Neurosurgery and Psychiatry
. (2008)
doi: 10.1136/jnnp.2007.139345
Click on
Right here to See Article On-line
(useful resource now not out there at

Written by: Peter M Crosta

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